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Case Report
Four Cases of Staphylococcal Scalded Skin Syndrome
Chul Han Park, Yoo Jin Jeong, Won Jung Choi, Sat Byul Park, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2004;47(1):106-110.   Published online January 15, 2004
Staphylococcal scalded skin syndrome is a systemic disease with a clinical spectrum ranging from subcorneal pustules, patterned exfoliation to extensive erosion and peeling of skin by the exfoliative toxin of group II Staphylococcus aureus. This disease occurs mainly in infancy and children below five years and it isn't easy to differentiate from other vesicular diseases clinically, but skin biopsy shows...
Original Article
Endoscopic Findings of Children with Henoch-Schonlein Purpura
Dong Hoon Lee, Chul Han Park, Ji Min Park, Geun Soo Park, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2003;46(6):572-575.   Published online June 15, 2003
Purpose : This study was performed to analyze the endoscopic findings in Henoch-Schonlein purpura patients, and to compare the differences in endoscopic findings according to age and gastrointestinal symptoms. Methods : We examined children with Henoch-Schonlein purpura aged 3 to 15 years between September 1996 and October 2002. The total number studied was 65, consisting of 41 boys and 24...
Case Report
MRI Finding of a Case of Relapsed Acute Mixed Type Leukemia with Bone Marrow Necrosis
Joo Young Park, Euk Park, Seat Byeoul Park, Dong Seok Jeon, Hee Jung Lee, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2002;45(2):256-260.   Published online February 15, 2002
Bone marrow necrosis is a rare complication of a variety of diseases affecting the marrow. The cause and incidence are unknown, and reports of treatment response are rare. We describe a case of relapsed acute mixed type leukemia with bone marrow necrosis. The patient was a 10 year old female diagnosed with acute mixed type leukemia four years ago. She...
Original Article
Infectious Manifestations in Childhood Leukemia
Yoon Jung Cho, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2001;44(9):1019-1030.   Published online September 15, 2001
Purpose : Infection is one of the major causes of morbidity and mortality in children during chemotherapy for leukemia and the development of fever in neutropenic cancer patients frequently indicates infection. The purpose of the present study is to evaluate infectious manifestations during the course of leukemia. Methods : Seventy eight leukemic children who had one or more occasions of infection during hospitalization from January...
Case Report
A Case of Relapsed Acute Promyleocytic Leukemia Induced Remission with Arsenic Trioxide(As2O3)
Jin Hye Park, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(8):1132-1136.   Published online August 15, 2000
Acute promyelocytic leukemia(APL) is a unique entity in the spectrum of acute myelogenous leukemia. It has several characteristic features, including distinctive morphology, chromosomal translocation, t(15:17), disseminated intravascular coagulation and effect on retinoic acid. Retinoic acid which is a derivative of vitamin A induces differentation of APL cells in vitro and in vivo, but its cessation induces relapse of APL. Arsenic...
A Case of Acute Leukemia Remitted by Adding Cyclosporin-A Previously Failed with Induction Therapy
Seat Byeoul Park, Byung Kyu Choe, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(7):988-992.   Published online July 15, 2000
Clinical chemotherapy refractoriness is characterized by resistance to multiple drugs. Multidrug resistance(MDR) is caused by over-reactivity of a unidirectional drug efflux pump, transmembrane glycoprotein(P-glycoprotein), which is encoded by the MDR1 gene. P-glycoprotein leads to increased drug efflux and decreased intracellular drug concentration. Clinical trials that attempt to reverse or modulate MDR have been done. Cyclosporin-A and verapamil are the most extensively studied agents and several...
Original Article
Clinical Manifestation of Childhood Acute Leukemia with Bone Involvement
Kyoung Eun Jeong, Hee Jung Lee, Kwang Soon Song, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(6):806-813.   Published online June 15, 2000
Purpose : Bone involvement is known to develop in 40-70% of pediatric acute leukemia. We aimed to analyze the clinical course and result of therapy in pediatric acute leukemia with bone involvement. Methods : Twenty-seven patients diagnosed as pediatric acute leukemia at Dong San Medical Center from Jan. 1996 to Aug. 1998 were evaluated. According to bone X-ray and whole body...
Anticancer Effect of Arsenic Trioxide in Acute Promyelocytic Leukemia
Ki Young Song, Jin Hye Park, Yoon Jung Cho, Won Ki Baek, Ki Young Kwon, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(3):327-334.   Published online March 15, 2000
Purpose : Acute promyelocytic leukemia(APL or AML, M3) represents an unique model for cancer research in terms of biological and clinical features. Since 1988, it has been widely confirmed that all-trans retinoic acid(ATRA) can induce complete clinical remission in over 85% of APL patients by a differentiation process, with PML-RARα protein possibly being the direct target of ATRA. However, ATRA...
Erratum
Childhood Cancer and Infection
Chin Moo Kang
Clin Exp Pediatr. 2000;43(3):315-321.   Published online March 15, 2000
Original Article
Chemosensitivity Test of Childhood Leukemic Cells
Tae Woong Ha, Su Kyung Jung, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 1999;42(8):1111-1121.   Published online August 15, 1999
Purpose : The purpose of the present study is to determine the relation between in vitro resistance to 9 drugs, measured with colorimetric methylthiazol tetrazolium(MTT) assay and prognostic factors. Methods : Thirty children with leukemia were evaluated at the pediatric department of Dongsan Medical Center. All samples tested with the MTT assay contained 80% or more leukemic cells, which were isolated...
Surgical Treatment for Intractable Childhood Epilepsy
Yoon Jung Cho, Chun Soo Kim, Joon Sik Kim, Chin Moo Kang, Ji Eun Kim, Sang Do Yi, Eun Ik Son
Clin Exp Pediatr. 1998;41(11):1565-1574.   Published online November 15, 1998
Diagnostic Value of Stable Microbubble Rating Test and Shake Test for the Early Detection of Respiratory Distress Syndrome in Prematurity
Sung Eun Lee, Sang Lak Lee, Chin Moo Kang
Clin Exp Pediatr. 1994;37(11):1500-1507.   Published online November 15, 1994
Respiratory distress syndrome (RDS) of newborn is a disease revealed high morbidity and mortality rate, especially in premature infant. To evaluate the predictive value of Stable Microbubble Rating (SMR) and Shake test on RDS in premature infant, the anthors carried out the gastric aspirates Shake test and SMR test at birth, 3 and 6 hours after birth respectively on 124 premature...
Urinary Red Cell Volume in the Diagnosis of Glomerular and Non-Glomerular Heaturia in children
Jong Sul Kwon, Dong Seok Kim, Myung Sung Kim, Joon Sik Kim, Chin Moo Kang, Dong Seok Jeon
Clin Exp Pediatr. 1994;37(1):40-46.   Published online January 15, 1994
Hematuria is a important clinical sign that is a consequence of significatn renal, urologic or sytemic disease. Recently the morphology of the red cell in hematuria has been used to indicate a renal or non-renal source and also the measurement of red cell volume by red cell analyzer has been used to distinguish glomerular from non-glomerular hematuria. In this study, the...
Case Report
Two Cases of Gaucher's Disease in Brothers
Seung Beum Cho, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 1993;36(12):1752-1760.   Published online December 15, 1993
We experienced two cases of Gaucher's disease of adult type in brother aged four years and two years. The patients showed hepatosplenomegaly with anemia and thrombocytopenia. Typical Gaucher cells were found in bone marrow and biopsy specimens of liver and spleen through light and electron microscopic examination. Splenectomy was followed by improvement of anemia and thrombocytopenia. A brief review of...
Original Article
Clincal Study on 12 Cases of Neonatal Group B β-Hemolytic Streptococcal Meningitis
Won Jin Kim, Sang Woog Lee, Sang Lak Lee, Myung Sung Kim, Chin Moo Kang
Clin Exp Pediatr. 1993;36(11):1507-1515.   Published online November 15, 1993
A clinical study was made on 12 cases of neonatal Group Bβ-hemolytic streptococcal(=GBS)meningitis, who were admitted to the department of Pediatrics, Dong-San Hospital, Keimyung University during the period of 3 years from Aug 1989 to Jul 1992. The following results were obtained 1) GBS was cultured in 12 cases(57.1%) among 21 neonatal meningitis admitted during the same period. 2) Male and female ratio...
Plasma Norepinephrine Levels in Infants and Children with Congestive Heart Failure
Sang Woog Lee, Myung Sung Kim, Sang Lak Lee, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1993;36(7):982-986.   Published online July 15, 1993
To characterize the sympathetic nervous system response to congestive heart failure in infants and children, plasma norepinephrine levels were measured in 29 patients aged 4 months to 15 years undergoing routine cardiac catheterization at Dong San Hospital, Keimyung University during the period of 4 months from November 1990 to February 1991. Plasma norepinephrine levels were significantly higher in patients with heart...
A case of acute megakaryoblastic leukemia with Down syndrome.
Sung Jin Chang, Sung Min Sohn, Heung Sik Kim, Chin Moo Kang, Dong Seok Jeon
Clin Exp Pediatr. 1991;34(12):1730-1735.   Published online December 31, 1991
We experienced a case of acute megakaryoblastic leukemia (M7) with Down syndrome. The patient was admitted due to premature SGA, which revealed characteristic facial figure of Down syndrome. M7 was diagnosed with PB smear which showed abundant megakaryoblast and confirmed by using the monoclonal antiplatelet glycoprotein IIb/IIIa antibody (J 15). On 25th hospital day, the patient gained weight but discharged without further treatment of M7. Authors...
Upper gastrointestinal diseases diagnosed by upper gastrointestinal fiberoptic endoscopy in children.
Jong Moon Hwang, Pal Dong Kim, Tae Won Paik, Chin Moo Kang
Clin Exp Pediatr. 1991;34(2):217-222.   Published online February 28, 1991
A clinical analysis was carried out on 83 cases of upper gastrointestinal diseases, diagnosed by fiberoptic endoscopic examination in children, who had visited the department of pediatrics, Keimyung University, Dong San Hospital from January 1980 to June 1987. Following results were obtained: Out of 83 cases, 61 (73.5%) were between 11-15 years of age and the male to female ratio was 3. 6:1. The disease distribution...
Therapeutic effects of plasmapheresis in Guillian-Barre syndrome.
Sung Jin Chang, Sun Hee Jung, Eun Sook Suh, Chin Moo Kang
Clin Exp Pediatr. 1991;34(1):66-73.   Published online January 31, 1991
Although the exact mechanism of the immunologic injury is unknown, the pathogenesis of the Guillain-Barr受 syndrome is explained as an autoimmune attack directed against to peripheral nervous myelin. So plasmapheresis is tried for treatment of Guillain-Barr즌 syndrome. Authors analysed 12 cases af Guillain-Barr受 syndrome who were treated with plasmapheresis and compared the results with that of the 13 cases, treated with conventional therapy. Duration between...
A Case of Interrupted Aortic Arch.
Yeong Sook Kang, Sun Hee Jung, Tae Chan Kwon, Chin Moo Kang, Seok Kil Zeon, Kwang Sook Lee, Yeong Sun Yoo
Clin Exp Pediatr. 1990;33(11):1579-1585.   Published online November 30, 1990
Interrupted aortic arch is a congenital anomaly in which discontinuity is present between ascending and descending aorta, and is associated frequently with ventricular septal defect and patent ductus arteriosus. Authors experienced a case of interrupted aortic arch in a 4 year old boy associated with a ventriculalr septal defect and patent ductus arteriosus. Diagnostic confirmation was made by 2-D echocardiography, cardiac cathetrization and angiogra- phy. Direct closure...
Relationship between anaphylactoid purpura and Beta-Hemolytic Streptococcal Infection.
Ji Eun Lee, Young Sook Kang, Joon Sik Kim, Sung Ho Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(9):1231-1236.   Published online September 30, 1990
Relationship between anaphylactoid purpura and beta-hemolytic streptococcal infection was obser- ved and analyzed through clinical manifestation and labortory findings in 146 cases of allergic purpura, hospitalized at Dongsan hospital, Keimyung University during the period from January, 1981 to May, 1987. The following results were obtained. 1) The age distribution of anaphylactoid purpura showed a peak incidence between 2 to 7 years of age and male preponderance was...
Vitamin K Dependent Hemorrhagic Disease of the Newborn and Infancy with Intracranial Hemorrhage.
Ji Eun Lee, Pal Dong Kim, Hong Dae Cha, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(9):1209-1215.   Published online September 30, 1990
Eight cases of vitamin K dependent hemorrhagic disease of the newborn and infancy with intra- cranial hemorrhage were analysed clinically. Out of 8 cases, 3 cases developed the bleeding within 7 day of life and 5 cases after one month. Two cases had bleeding before initial feeding. Out of 6 cases who were fed before the onset of bleeding, 4 cases had breast feeding. Neurological...
Correlation among Electrocardiographic, Echocardigraphic and Hemodynamic Analysis in Atrial Septal Defect, Ostium Secundum type.
Soon Jung Lee, Chi Han Kwon, Joon Sik Kim, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1990;33(7):946-951.   Published online July 31, 1990
The electrocardiographic, echocardiographic and hemodynamic analysis were made on 32 patients with atrial septal defect of ostium secundum type, who were diagnosed by echocardiography, right heart catheterization at Dong San Hospital, Keimyung University during the period of 5 years and 6 months from Jaunary 1982 to June 1987. Following results were obtained. Out of 32 patients, 14 were male and 18 were female. Their ages...
Comparisons of the Pressure Gradients between Two-Dimensional Echocardiographic Doppler Studies and Cardiac Catheterization in Pulmonary Stenosis.
Won Ho Choi, Young Sook Kang, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1990;33(7):940-945.   Published online July 31, 1990
The right ventricular outflow tract pressure gradient measured by Doppler echocardiography was compared with the pressure gradient by cardiac catheterization in 19 children who were admitted to the department of Pediatrics, Dong San Hospotal during the period of 18 months from January 1987 to June 1988 for the evaluation of heart disease. Among 19 cases, 10 cases were Tetralogy of Fallot, 5 cases were...
A Case of Dermatomyositis.
Pal Dong Kim, Chi Han Kwon, Eun Sook Suh, Chin Moo Kang
Clin Exp Pediatr. 1990;33(6):870-878.   Published online June 30, 1990
Dermatomyositis is a rarely recognized disorder with poor prognosis. The mortality has been decreased after the initiation of steroid for ifs treatment. Authors experienced a case of der- matomyositis responded well to prednisone therapy and developed hyperglycemia laterly. A 14 year old boy was admitted to pediatric ward with the chief complaints of progressive muscular weakness and facial rash and diagnosed as having dermatomyositis...
Four Cases of Childhood Systemic Lupus Erythematosus.
Jun Ah Jeong, Young Mi Kim, Eun Sook Suh, Sung Ho Kim, Chin Moo Kang, Sang Sook Lee, Chai Hong Chung
Clin Exp Pediatr. 1990;33(2):264-273.   Published online February 28, 1990
Systemic Lupus Erythematosus (SLE) is a rare entity in pediatric age and prognosis is poor due to higher incidence of renal involvement in children. Authors experienced four cases of SLE, aged between 9-13 years. All cases were female. The diagnosis was based on “The 1982 revised criteria for SLE (by American Rheumatism Association). All cases had fever on admission and the butterfly facial rash was...
Cytogenetic Analysis of Chromosomal Abnormalities in Children.
Key Young Song, Kwang Man Kim, Joon Sik Kim, Hong Dae Cha, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(2):153-161.   Published online February 28, 1990
The present report described the cytogenetic findings in 273 cases under the age of 15 years who were suspected as having chromosomal abnormalities clinically. The cytogenetic analysis was conducted at chromosome laboratory of Keimyung University School of Medicne, from September 1982 to June 1987. The following results were obtained. Chromosomal abnormalities were found in 85 (31.3%) of the cases studied. Of 85 cases, 41 cases (85.9%)...
Clinical Study on Hypernatremic Dehydration in Children.
Young Mi Kim, Key Young Song, Sung Ho Kim, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1990;33(2):146-152.   Published online February 28, 1990
The clinical study was done on 68 cases of hypernatremic dehydration which were diagnosed at pediatric department of Dong-san Hospital Keimyung University during the period from January 1980 to June 1987. The results were as follows; 1) Among 672 cases with dehydration, hypernatremic dehydration was 10.1% 2) The higer monthly distribution was in May and November. 3) Out of 68 cases, 61 cases (89.7%) were under the 6 months...
The Hemodynamics and Electrocardiogram in Isolated Ventricular Septal Defect.
Kwang Man Kim, Ki Young Song, Sang Kwon Lee, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1989;32(8):1098-1105.   Published online August 31, 1989
Ventricular septal defect is the most common cardiac malformation, accounting for 25% of congenital heart disease. The electrocardiogram is becoming more useful as a tool in estimating the size of the ventricular septal defect and the type of pulmonary vascular response. This report comprises 210 patients in whom the diagnosis of isolated ventricular septal defect was made by cardiac catheterization and angiocardiography at Dong San...
Abdaninal Tumor in Infants and Children.
Young Soo Kim, Kwang Man Kim, Seung Ho Kim, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1989;32(3):366-374.   Published online March 31, 1989
Eighty seven patints with abdominal tumor which were diagnosed with abdominal C-T scan and confirmed histologically were reviewed. These patients were admitted to pediatric department of Dong San Medical Canter from January, 1980 to June, 1986. The results were as follows; Out of 87 patients, 30 (34.5%) were intraperitoneal and 57 (65.5%) were retroperitoneal tumor. Among intraperitoneal tumor, 15 cases (50%) were hepatosplenomegaly, and among...
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